Endocrine Abstracts

Chlorpyrifos (CPF) is a worldwide used organophosphate insecticide for controlling many types of pests in the household, farm and residential settings. It has the potential to negatively affect the reproductive system and fertility. Nigella sativa has been used both as seeds or oil to promote health and fight disease. Hence, the present work was undertaken to evaluate the possible protective role of Nigella sativa oil (NSO) against chlorpyrifos induced reproductive toxicity in...

Nicotine (N) is known as the main toxic and addictive component of cigarette smoke. By its ability to generate reactive oxygen species (ROS) and oxidative damage in organism, it can induce major public health problems such as cancer, cardiovascular diseases and infertility. Green tea extract (GTE) is an important source of polyphenols catechins; it has attracted a great deal of attention around the world because of its potential antioxidants role in scavenging free radicals. T...

A 27 years old primigravid lady presented with nausea and recurrent vomiting at 35 weeks gestation. She was diagnosed with hyperemesis gravidarum at 5 weeks gestation. TPN was commenced but she continued vomiting. On examination, foetal size was normal for gestational age, BP was 105/70 mmHg. Electrolytes were normal except potassium of 2.7 mmol/l, LFT was normal, albumin 29 g/l and uric acid 307 umol/l. 16 days after admission, she rapidly deteriorated with weakness and plasm...

Introduction: Hyperthyroidism owing to Graves’ disease or toxic nodular goiter is a common condition seen in clinical practice. The available modes of therapy are antithyroid drugs, surgery and radioiodine (RAI) therapy. Radioiodine is an effective, safe and relatively inexpensive form of therapy in patients suffering from hyperthyroidism. The aim of our study is to assess the effectiveness of radioactive iodine (RAI) treatment in patients with hyperthyroidism.<p clas...

Introduction: Graves’ ophthalmopathy (GO) is an autoimmune disorder affecting the retro-orbital tissues. It represents the main extra- thyroidal expression of Graves’ disease (GD). In children, GO is less common and less severe than in adults. Herein we report a case of GO in a child.Case report: An 11-year-old girl with family history of autoimmune thyroid disease was referred to our department for evaluation of suspected hyperthyroidism. She ...

Introduction: The coexistence of two types of tumors of different origins in the same thyroid is a rare phenomenon. Its etiopathogenesis remains unknown. We report the case of a mixed papillary and medullary carcinoma of the thyroid revealed by a compressive goiter.Case report: A 70-year old woman with a history of right lobo-isthmusectomy for a toxic solitary adenoma, presented 30 years later with a chief complaint of a cervical mass accompanied by diff...

Introduction: The COVID-19 pandemic had a significant emotional and psychological impact on populations worldwide, especially vulnerable people with chronic diseases such as diabetics. The objective of our study was to assess the quality of life and psychological distress of diabetic patients and to study patients’ attitudes towards managing their diabetes.Methods: We conducted a cross sectional descriptive study involving 60 diabetic patients follo...

Introduction: Hyponatremia is a commonly associated with atypical pneumonia. One of its pathophysiological mechanisms is inappropriate antidiuretic hormone secretion(SIADH). We describe the case of a patient presenting an SIADH caused by COVID19 infection.Observation: We report a case of a 70-year-old man, known to have well-controlled hypertension, with a medical history of cavum’s neoplasia treated with radiotherapy and hypothyroidism post thyroid...

Introduction: Precocious puberty (PP) is a rare pathology involving approximatively 0.2% of girls and less than 0.05% of boys and is defined as the appearance of secondary sex characteristics before 8 years of age in girls and before 9 years of age in boys. We report an unusual case of a patient who presents a precocious puberty associated to a primary adrenal insufficiency.Case presentation: We describe a case of a 7-year and 4 months old girl referred ...

Introduction: Patients with hypothyroidism usually gain weight, and those with hyperthyroidism lose weight. Body weight changes related with thyroid dysfunction support the idea that thyroid hormones have an effect on body weight and body composition. The aim of our study was to describe the clinical profile and body composition of Tunisian patients who were newly diagnosed with hypothyroidism.Methods: This was a cross-sectional and descriptive study inc...